1-(3-Aminopropyl)-4-methylpiperazine → HCID 67492329, compound

HRID 1921414Notes

Reaction equation

HRID 1921414 reaction equation
[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[S:15][C:14]([S:16]([Cl:19])(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[CH3:20][N:21]1[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][CH2:29][NH2:30])[CH2:23][CH2:22]1>>[ClH:19].[ClH:19].[CH3:20][N:21]1[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][CH2:29][NH:30][S:16]([C:14]2[S:15][C:11]([C:5]3[CH:4]=[C:3]([CH2:1][CH3:2])[C:8](=[O:9])[NH:7][C:6]=3[CH3:10])=[CH:12][CH:13]=2)(=[O:18])=[O:17])[CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 783281-(3-Aminopropyl)-4-methylpiperazineHCID 866103525-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride

Product 1

HCID 67492329HCID 67492329, compoundYield 80%

Procedure

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with 3-(4-methylpiperazin-1-yl)propylamine as described in Steps 5 and 6, Example 24 to give the title compound as a white solid (80% yield). LC/MS: RT 1.82 min; m/e 439; 1H NMR (δ, ppm): 8.01 (1H, s), 7.56 (1H, d), 7.35 (1H, s), 7.18 (1H, d), 2.70-3.60 (m), 2.40 (2H, q), 2.33 (3H, s), 2.50-2.10 (6H, m), 1.89 (2H, m), 1.09 (3H, t).

Sources & evidence

ORD record
ord-1ee4c8a2d91b4a2d8c0ce93361bf655a
Source dataset
uspto-grants-2012_05
Patent number
US08173682B2

Reaction notes

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