1-(3-Aminopropyl)-4-methylpiperazine → HCID 67492329, compound

Participants

Reaction Steps

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with 3-(4-methylpiperazin-1-yl)propylamine as described in Steps 5 and 6, Example 24 to give the title compound as a white solid (80% yield). LC/MS: RT 1.82 min; m/e 439; 1H NMR (δ, ppm): 8.01 (1H, s), 7.56 (1H, d), 7.35 (1H, s), 7.18 (1H, d), 2.70-3.60 (m), 2.40 (2H, q), 2.33 (3H, s), 2.50-2.10 (6H, m), 1.89 (2H, m), 1.09 (3H, t).

Provenance & Evidence