2-Morpholin-4-yl-2-(3-pyridyl)ethylamine → HCID 67492336, compound

HRID 1921419Notes

Reaction equation

HRID 1921419 reaction equation
[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[S:15][C:14]([S:16]([Cl:19])(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[N:20]1([CH:26]([C:29]2[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=2)[CH2:27][NH2:28])[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>>[ClH:19].[ClH:19].[N:20]1([CH:26]([C:29]2[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=2)[CH2:27][NH:28][S:16]([C:14]2[S:15][C:11]([C:5]3[CH:4]=[C:3]([CH2:1][CH3:2])[C:8](=[O:9])[NH:7][C:6]=3[CH3:10])=[CH:12][CH:13]=2)(=[O:18])=[O:17])[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 49889912-Morpholin-4-yl-2-(3-pyridyl)ethylamineHCID 866103525-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride

Product 1

HCID 67492336HCID 67492336, compoundYield 55%

Procedure

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with 2-(morpholin-4-yl)-2-(pyridin-3-yl)ethylamine as described in Steps 5 and 6, Example 24 to give the title compound as a white solid (55% yield). LC/MS: RT 2.06 min; m/e 489; 1H NMR (δ, ppm): 11.85 (1H, br), 8.98 (1H, s), 8.86 (1H, d), 8.54 (1H, d), 7.90 (2H, t), 7.58 (1H, t), 7.34 (1H, s), 7.1.7 (1H, d), 4.65 (1H, br), 3.6-4.10 (8H, br), 2.8-3.1 (2H, br), 2.40 (2H, q), 2.33 (3H, s), 1.10 (3H, t).

Sources & evidence

ORD record
ord-c49054568ff54a749466aa3771febb6b
Source dataset
uspto-grants-2012_05
Patent number
US08173682B2

Reaction notes

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