1-(Cyclohexylmethyl)piperidin-4-amine → HCID 69539633, compound

HRID 1921422Notes

Reaction equation

HRID 1921422 reaction equation
[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[S:15][C:14]([S:16]([Cl:19])(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[CH:20]1([CH2:26][N:27]2[CH2:32][CH2:31][CH:30]([NH2:33])[CH2:29][CH2:28]2)[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1>>[ClH:19].[CH:20]1([CH2:26][N:27]2[CH2:32][CH2:31][CH:30]([NH:33][S:16]([C:14]3[S:15][C:11]([C:5]4[CH:4]=[C:3]([CH2:1][CH3:2])[C:8](=[O:9])[NH:7][C:6]=4[CH3:10])=[CH:12][CH:13]=3)(=[O:18])=[O:17])[CH2:29][CH2:28]2)[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]1

Participants

3

Reactant 2

HCID 64969411-(Cyclohexylmethyl)piperidin-4-amineHCID 866103525-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride

Product 1

HCID 69539633HCID 69539633, compoundYield 73%

Procedure

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with (1-cyclohexylmethylpiperidin-4-yl)amine as described in Steps 5 and 6, Example 24 to give the title compound as a white solid (73% yield). LC/MS: RT 2.28 min; m/e 478; 1H NMR (δ, ppm): 11.85 (1H, br), 9.80 (1H, br), 8.18-8.37 (1H, m), 7.54-7.65 (1H, m), 7.34 (1H, s), 7.17 (1H, d), 2.70-3.75 (7H, m), 2.40 (2H, q), 2.32 (3H, s), 1.50-2.08 (10H, m), 0.80-1.35 (8H, m).

Sources & evidence

ORD record
ord-12e49d03e4e4440c80546abacca0e3d1
Source dataset
uspto-grants-2012_05
Patent number
US08173682B2

Reaction notes

Loading…