1-(Cyclohexylmethyl)piperidin-4-amine → HCID 69539633, compound

Participants

Reaction Steps

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with (1-cyclohexylmethylpiperidin-4-yl)amine as described in Steps 5 and 6, Example 24 to give the title compound as a white solid (73% yield). LC/MS: RT 2.28 min; m/e 478; 1H NMR (δ, ppm): 11.85 (1H, br), 9.80 (1H, br), 8.18-8.37 (1H, m), 7.54-7.65 (1H, m), 7.34 (1H, s), 7.17 (1H, d), 2.70-3.75 (7H, m), 2.40 (2H, q), 2.32 (3H, s), 1.50-2.08 (10H, m), 0.80-1.35 (8H, m).

Provenance & Evidence