1-Methylpiperazine → HCID 58808674, compound

Participants

Reaction Steps

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with 1-methylpiperazine as described in Steps 5 and 6, Example 24 to give the title compound as a solid (63.3% yield). LC/MS: RT 2.07 min; m/e 382 (M+H); 1H NMR (δ, ppm): 11.8 (1H, s), 11.3 (1H, s), 7.7 (1H, d); 7.4 (1H, s); 7.32 (1H, d), 4.8 (2H, m), 3.5 (2H, d), 3.2 (2H, m), 2.9 (2H, t), 2.75 (3H, s), 2.4 (2H, q), 2.36 (3H, s), 1.1 (3H, t).

Provenance & Evidence