1-Methylpiperazine → HCID 58808674, compound

HRID 1921431Notes

Reaction equation

HRID 1921431 reaction equation
[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[S:15][C:14]([S:16](Cl)(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[CH3:20][N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[S:15][C:14]([S:16]([N:24]3[CH2:25][CH2:26][N:21]([CH3:20])[CH2:22][CH2:23]3)(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 866103525-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride

Product 1

HCID 58808674HCID 58808674, compoundYield 63.3%

Procedure

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with 1-methylpiperazine as described in Steps 5 and 6, Example 24 to give the title compound as a solid (63.3% yield). LC/MS: RT 2.07 min; m/e 382 (M+H); 1H NMR (δ, ppm): 11.8 (1H, s), 11.3 (1H, s), 7.7 (1H, d); 7.4 (1H, s); 7.32 (1H, d), 4.8 (2H, m), 3.5 (2H, d), 3.2 (2H, m), 2.9 (2H, t), 2.75 (3H, s), 2.4 (2H, q), 2.36 (3H, s), 1.1 (3H, t).

Sources & evidence

ORD record
ord-801634ef0a8642fbb381eb3d61833537
Source dataset
uspto-grants-2012_05
Patent number
US08173682B2

Reaction notes

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