N,N-Dimethylethylenediamine → HCID 71082982, compound

HRID 1921432Notes

Reaction equation

HRID 1921432 reaction equation
[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[S:15][C:14]([S:16]([Cl:19])(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[CH3:20][N:21]([CH3:25])[CH2:22][CH2:23][NH2:24]>>[ClH:19].[CH3:20][N:21]([CH3:25])[CH2:22][CH2:23][NH:24][S:16]([C:14]1[S:15][C:11]([C:5]2[CH:4]=[C:3]([CH2:1][CH3:2])[C:8](=[O:9])[NH:7][C:6]=2[CH3:10])=[CH:12][CH:13]=1)(=[O:18])=[O:17]

Participants

3

Reactant 2

HCID 66053N,N-DimethylethylenediamineHCID 866103525-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride

Product 1

HCID 71082982HCID 71082982, compoundYield 44.3%

Procedure

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with 2-(dimethylamino)ethylamine as described in Steps 5 and 6, Example 24 to give the title compound as a solid (44.3% yield). LC/MS: RT 1.97 min; m/e 370 (M+H); 1H NMR (δ, ppm): 11.8 (1H, s), 10.3 (1H, s), 8.3 (1H, t); 7.65 (1H, d); 7.35 (1H, s), 7.2 (1H, d), 4.2 (2H, m), 3.8 (6H, m), 2.4 (2H, q), 2.36 (3H, s), 1.1 (3H, t).

Sources & evidence

ORD record
ord-35e96e2a466b49deb44797be2bfefadb
Source dataset
uspto-grants-2012_05
Patent number
US08173682B2

Reaction notes

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