2-Phenoxyethanamine → HCID 58808634, compound

HRID 1921437Notes

Reaction equation

HRID 1921437 reaction equation
[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[S:15][C:14]([S:16](Cl)(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[O:20]([CH2:27][CH2:28][NH2:29])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[O:20]([CH2:27][CH2:28][NH:29][S:16]([C:14]1[S:15][C:11]([C:5]2[CH:4]=[C:3]([CH2:1][CH3:2])[C:8](=[O:9])[NH:7][C:6]=2[CH3:10])=[CH:12][CH:13]=1)(=[O:18])=[O:17])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 156512-PhenoxyethanamineHCID 866103525-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride

Product 1

HCID 58808634HCID 58808634, compoundYield 78%

Procedure

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with 2-phenoxy-ethylamine as described in Step 5, Example 24 to give the title compound as a yellow-orange solid (78% yield). LC/MS: RT 3.00 min; m/e 419 (M+H); 1H NMR (δ, ppm): 11.82 (1H, s), 8.18 (1H, m), 7.58 (1H, dd), 7.23-7.29 (3H, m), 7.15 (1H, dd), 6.86-6.94 (3H, m), 3.99 (2H, t), 3.28 (2H, t), 2.40 (2H, q), 2.29 (3H, s), 1.09 (3H, t).

Sources & evidence

ORD record
ord-1d6fb40b39c84558b940300d4be8f355
Source dataset
uspto-grants-2012_05
Patent number
US08173682B2

Reaction notes

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