3-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-propyl amine → HCID 58808542, compound

HRID 1921460Notes

Reaction equation

HRID 1921460 reaction equation
[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[S:15][C:14]([S:16](Cl)(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[CH2:20]([N:22]1[CH2:26][CH2:25][CH2:24][CH:23]1[CH2:27][NH:28][CH2:29][CH2:30][CH2:31][NH2:32])[CH3:21]>>[CH2:20]([N:22]1[CH2:26][CH2:25][CH2:24][CH:23]1[CH2:27][NH:28][CH2:29][CH2:30][CH2:31][NH:32][S:16]([C:14]1[S:15][C:11]([C:5]2[CH:4]=[C:3]([CH2:1][CH3:2])[C:8](=[O:9])[NH:7][C:6]=2[CH3:10])=[CH:12][CH:13]=1)(=[O:18])=[O:17])[CH3:21]

Participants

3

Reactant 2

HCID 674923653-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-propyl amineHCID 866103525-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride

Product 1

HCID 58808542HCID 58808542, compoundYield 19%

Procedure

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with 3-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-propyl amine as described in Step 5, Example 24 to give the title compound (19% yield). LC/MS: RT 2.19 min; m/e 467 (M+H).

Sources & evidence

ORD record
ord-d49031b62e674c31b74a6a34abe891d1
Source dataset
uspto-grants-2012_05
Patent number
US08173682B2

Reaction notes

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