2-(3,3-Difluoropyrrolidin-1-yl)ethan-1-amine → HCID 58808606, compound

HRID 1921461Notes

Reaction equation

HRID 1921461 reaction equation
[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[S:15][C:14]([S:16](Cl)(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[F:20][C:21]1([F:29])[CH2:25][CH2:24][N:23]([CH2:26][CH2:27][NH2:28])[CH2:22]1>>[F:20][C:21]1([F:29])[CH2:25][CH2:24][N:23]([CH2:26][CH2:27][NH:28][S:16]([C:14]2[S:15][C:11]([C:5]3[CH:4]=[C:3]([CH2:1][CH3:2])[C:8](=[O:9])[NH:7][C:6]=3[CH3:10])=[CH:12][CH:13]=2)(=[O:18])=[O:17])[CH2:22]1

Participants

3

Reactant 2

HCID 534035522-(3,3-Difluoropyrrolidin-1-yl)ethan-1-amineHCID 866103525-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride

Product 1

HCID 58808606HCID 58808606, compoundYield 43%

Procedure

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with 2-(3,3-difluoro-pyrrolidin-1-yl)-ethylamine as described in Step 5, Example 24 to give the title compound (43% yield). LC/MS: RT 1.32 min; m/e 432 (M+H).

Sources & evidence

ORD record
ord-fc3cc13f187e4707a56189b5be66ea2b
Source dataset
uspto-grants-2012_05
Patent number
US08173682B2

Reaction notes

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