HCID 63653380, compound → HCID 58808602, compound

HRID 1921462Notes

Reaction equation

HRID 1921462 reaction equation
[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[S:15][C:14]([S:16](Cl)(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[NH2:20][CH2:21][CH2:22][N:23]1[CH2:27][CH2:26][CH2:25][CH:24]1[C:28]([OH:30])=[O:29]>>[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[S:15][C:14]([S:16]([NH:20][CH2:21][CH2:22][N:23]3[CH2:27][CH2:26][CH2:25][CH:24]3[C:28]([OH:30])=[O:29])(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 63653380HCID 63653380, compoundHCID 866103525-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride

Product 1

HCID 58808602HCID 58808602, compoundYield 88%

Procedure

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with 1-(2-aminoethyl)-pyrrolidine-2-carboxylic acid as described in Step 5, Example 24 to give the title compound (88% yield). LC/MS: RT 2.04 min; m/e 440 (M+H).

Sources & evidence

ORD record
ord-cdbe3aea4f3b4f20a7d13dbc62f65494
Source dataset
uspto-grants-2012_05
Patent number
US08173682B2

Reaction notes

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