1-[(3,5-Difluorophenyl)methyl]piperidin-4-amine → 5-(5-{[1-(3,5-Difluoro-benzyl)-piperidin-4-ylamino]-methyl}-thiophen-2-yl)-3-ethyl-6-methyl-1H-pyridin-2-one

HRID 1921463Notes

Reaction equation

HRID 1921463 reaction equation
[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[S:15][C:14]([CH:16]=O)=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[F:18][C:19]1[CH:20]=[C:21]([CH:30]=[C:31]([F:33])[CH:32]=1)[CH2:22][N:23]1[CH2:28][CH2:27][CH:26]([NH2:29])[CH2:25][CH2:24]1>>[F:18][C:19]1[CH:20]=[C:21]([CH:30]=[C:31]([F:33])[CH:32]=1)[CH2:22][N:23]1[CH2:24][CH2:25][CH:26]([NH:29][CH2:16][C:14]2[S:15][C:11]([C:5]3[CH:4]=[C:3]([CH2:1][CH3:2])[C:8](=[O:9])[NH:7][C:6]=3[CH3:10])=[CH:12][CH:13]=2)[CH2:27][CH2:28]1

Participants

3

Reactant 2

HCID 221824001-[(3,5-Difluorophenyl)methyl]piperidin-4-amineHCID 588085435-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-carbaldehyde

Product 1

HCID 588086145-(5-{[1-(3,5-Difluoro-benzyl)-piperidin-4-ylamino]-methyl}-thiophen-2-yl)-3-ethyl-6-methyl-1H-pyridin-2-one

Procedure

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl]thiophen-2-carbaldehyde is reacted with 1-(3,5-difluoro-benzyl)-piperidin-4-ylamine as described in Method A of Example 123 to give the title compound. MS: m/e 458 (M+H).

Sources & evidence

ORD record
ord-421e3e6780a14f07b01f4f3851f0f0f0
Source dataset
uspto-grants-2012_05
Patent number
US08173682B2

Reaction notes

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