HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[(3,5-Difluorophenyl)methyl]piperidin-4-amine → 5-(5-{[1-(3,5-Difluoro-benzyl)-piperidin-4-ylamino]-methyl}-thiophen-2-yl)-3-ethyl-6-methyl-1H-pyridin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[(3,5-Difluorophenyl)methyl]piperidin-4-amine | HCID 22182400 | — |
| Reactant | 5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-carbaldehyde | HCID 58808543 | — |
| Product | 5-(5-{[1-(3,5-Difluoro-benzyl)-piperidin-4-ylamino]-methyl}-thiophen-2-yl)-3-ethyl-6-methyl-1H-pyridin-2-one | HCID 58808614 | — |
Reaction Steps
5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl]thiophen-2-carbaldehyde is reacted with 1-(3,5-difluoro-benzyl)-piperidin-4-ylamine as described in Method A of Example 123 to give the title compound. MS: m/e 458 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173682B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-421e3e6780a14f07b01f4f3851f0f0f0 |
| Source note | uspto-grants-2012_05 |