1-(Cyclopropylcarbonyl)piperazine → 5'-(4-Cyclopropanecarbonyl-piperazine-1-carbonyl)-5-ethyl-2-methyl-1H-[3,3']bipyridinyl-6-one

HRID 1921520Notes

Reaction equation

HRID 1921520 reaction equation
[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[CH:12]=[N:13][CH:14]=[C:15]([C:17]([OH:19])=O)[CH:16]=2)[CH:4]=1)[CH3:2].[CH:20]1([C:23]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[O:24])[CH2:22][CH2:21]1>>[CH:20]1([C:23]([N:25]2[CH2:30][CH2:29][N:28]([C:17]([C:15]3[CH:16]=[C:11]([C:5]4[CH:4]=[C:3]([CH2:1][CH3:2])[C:8](=[O:9])[NH:7][C:6]=4[CH3:10])[CH:12]=[N:13][CH:14]=3)=[O:19])[CH2:27][CH2:26]2)=[O:24])[CH2:21][CH2:22]1

Participants

3

Reactant 2

HCID 20642351-(Cyclopropylcarbonyl)piperazineHCID 588087025'-Ethyl-2'-methyl-6'-oxo-1',6'-dihydro-[3,3']bipyridinyl-5-carboxylic acid

Product 1

HCID 588086955'-(4-Cyclopropanecarbonyl-piperazine-1-carbonyl)-5-ethyl-2-methyl-1H-[3,3']bipyridinyl-6-one

Procedure

Method 1, Example 205 is substantially repeated except for utilizing 5′-ethyl-2′-methyl-6′-oxo-1′,6′-dihydro-[3,3′]bipyridinyl-5-carboxylic acid and 4-cyclopropanecarbonyl-piperazine to afford the title compound. MS: m/e=395 (M+H).

Sources & evidence

ORD record
ord-d3ec8d9c5c0b48eb8a9ce8eca32997c5
Source dataset
uspto-grants-2012_05
Patent number
US08173682B2

Reaction notes

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