Mafenide → 5'-Ethyl-2'-methyl-6'-oxo-1',6'-dihydro-[3,3']bipyridinyl-5-carboxylic acid 4-sulfamoyl-benzylamide
Reaction equation
[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[CH:12]=[N:13][CH:14]=[C:15]([C:17]([OH:19])=O)[CH:16]=2)[CH:4]=1)[CH3:2].[S:20]([C:24]1[CH:31]=[CH:30][C:27]([CH2:28][NH2:29])=[CH:26][CH:25]=1)(=[O:23])(=[O:22])[NH2:21]>>[S:20]([C:24]1[CH:25]=[CH:26][C:27]([CH2:28][NH:29][C:17]([C:15]2[CH:16]=[C:11]([C:5]3[CH:4]=[C:3]([CH2:1][CH3:2])[C:8](=[O:9])[NH:7][C:6]=3[CH3:10])[CH:12]=[N:13][CH:14]=2)=[O:19])=[CH:30][CH:31]=1)(=[O:22])(=[O:23])[NH2:21]Participants
3
Procedure
Method 1, Example 205 is substantially repeated except for utilizing 5′-ethyl-2′-methyl-6′-oxo-1′,6′-dihydro-[3,3′]bipyridinyl-5-carboxylic acid and 4-sulfamoyl-benzyl-amine to afford the title compound. MS: m/e=427 (M+H).
Sources & evidence
- ORD record
- ord-b17fa4edb307450781c07f7d80fb4c3e
- Source dataset
- uspto-grants-2012_05
- Patent number
- US08173682B2
Reaction notes
Loading…