1-(4-Fluorophenyl)piperazine → HCID 58808524, compound

HRID 1921536Notes

Reaction equation

HRID 1921536 reaction equation
[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[O:15][C:14]([C:16]([OH:18])=O)=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[F:19][C:20]1[CH:25]=[CH:24][C:23]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[CH:22][CH:21]=1>>[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[O:15][C:14]([C:16]([N:29]3[CH2:28][CH2:27][N:26]([C:23]4[CH:22]=[CH:21][C:20]([F:19])=[CH:25][CH:24]=4)[CH2:31][CH2:30]3)=[O:18])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 752601-(4-Fluorophenyl)piperazineHCID 674924175-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)furan-2-carboxylic acid

Product 1

HCID 58808524HCID 58808524, compoundYield 98%

Procedure

Method 1, Example 205 is substantially repeated except for utilizing 5-(5-ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)furan-2-carboxylic acid and (4-fluoro-phenyl)-piperazine to afford the title compound (98% yield). LC/MS: RT 2.9 min; m/e 410 (M+H).

Sources & evidence

ORD record
ord-06e5fbbca7fb4f9790f47f21e9da07eb
Source dataset
uspto-grants-2012_05
Patent number
US08173682B2

Reaction notes

Loading…