Benzenesulfonyl chloride → HCID 58808656, compound

HRID 1921555Notes

Reaction equation

HRID 1921555 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[C:12]([CH2:14][CH3:15])[C:11](=[O:16])[NH:10][C:9]=2[CH3:17])[CH:5]=[CH:4][CH:3]=1.[C:18]1([S:24](Cl)(=[O:26])=[O:25])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>N1C=CC=CC=1>[CH2:14]([C:12]1[C:11](=[O:16])[NH:10][C:9]([CH3:17])=[C:8]([C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([NH:1][S:24]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)(=[O:26])=[O:25])[N:7]=2)[CH:13]=1)[CH3:15]

Participants

4

Reactant 2

HCID 7369Benzenesulfonyl chlorideHCID 58808698HCID 58808698, compound

Product 1

HCID 58808656HCID 58808656, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

6-Amino-5′-ethyl-2′-methyl-1′H-[2,3′]bipyridinyl-6′-one (1 molar equivalent), prepared in accordance with the procedures of PREPARATION 12, is dissolved in pyridine (approx. 10 ml/mmol) and, at room temperature, 1.3 molar equivalent of benzene sulfonyl chloride is added, and the reaction mixture is stirred at room temperature for 36 hrs. The solution is completely concentrated and then purified directly by RP-HPLC. MS: m/e=370 (M+H).

Workup

  1. concentrationThe solution is completely concentrated
  2. custompurified directly by RP-HPLC

Sources & evidence

ORD record
ord-8871f36f472740e1939fb621c1e4727e
Source dataset
uspto-grants-2012_05
Patent number
US08173682B2

Reaction notes

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