Bromine → HCID 86643648, compound

HRID 1921680Notes

Reaction equation

HRID 1921680 reaction equation
[C:1]([CH:4]1[CH2:9][CH2:8][CH:7]([NH:10][C:11](=[O:27])[O:12][CH2:13][CH:14]2[C:26]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:20]3[C:15]2=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[Br:28]Br>CO>[CH:25]1[C:26]2[CH:14]([CH2:13][O:12][C:11](=[O:27])[NH:10][CH:7]3[CH2:6][CH2:5][CH:4]([C:1](=[O:3])[CH2:2][Br:28])[CH2:9][CH2:8]3)[C:15]3[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:21]=2[CH:22]=[CH:23][CH:24]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 69108330HCID 69108330, compound

Product 1

HCID 86643648HCID 86643648, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

7.77 g (21 mmol) of 9H-fluoren-9-ylmethyl (4-acetylcyclohexyl)carbamate (cis compound) is dissolved in 100 mL of methanol at ambient temperature and combined with 1.09 mL (21 mmol) of bromine. The mixture is stirred for 16 hours at ambient temperature, cooled, and the crystals precipitated are suction filtered. Yield: 6.35 g (50%); NMR: LG201641.

Workup

  1. temperaturecooled
  2. customthe crystals precipitated

Sources & evidence

ORD record
ord-6a01e464f6334b8ebfa61202c804c20a
Source dataset
uspto-grants-2012_05
Patent number
US08173699B2

Reaction notes

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