HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 7-(3,5-difluoro-4-triisopropylsilanyloxyphenyl)-6-formylheptanoate → Ethyl 6-(3,5-difluoro-4-triisopropylsilanyloxybenzyl)-8-[5-fluoro-2-(2-chlorobenzyloxy)phenyl]-oct-7-enoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 7-(3,5-difluoro-4-triisopropylsilanyloxyphenyl)-6-formylheptanoate | HCID 57971915 | — |
| Reactant | [2-(2-Chlorobenzyloxy)-5-fluorobenzyl]triphenylphosphonium bromide | HCID 86634289 | — |
| Product | Ethyl 6-(3,5-difluoro-4-triisopropylsilanyloxybenzyl)-8-[5-fluoro-2-(2-chlorobenzyloxy)phenyl]-oct-7-enoate | HCID 67493002 | — |
Reaction Steps
Reaction in analogy to Example 21A of [2-(2-chlorobenzyloxy)-5-fluorobenzyl]tri-phenylphosphonium bromide and ethyl 7-(3,5-difluoro-4-triisopropylsilanyloxyphenyl)-6-formylheptanoate results in the title compound with 70% of theory as E/Z mixture (2:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173704B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-e5e760b0d74a4debb2d4a5e744353f82 |
| Source note | uspto-grants-2012_05 |