Tert-butyl 3-oxopyrrolidine-1-carboxylate → 4-(6-methoxy-4-(pyrrolidin-3-ylamino)naphthalen-2-yl)-N-methylpyrimidin-2-amine

HRID 1921986Notes

Reaction equation

HRID 1921986 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=2)[CH:5]=[C:4]([C:14]2[CH:19]=[CH:18][N:17]=[C:16]([NH:20][CH3:21])[N:15]=2)[CH:3]=1.O=[C:23]1[CH2:27][CH2:26][N:25](C(OC(C)(C)C)=O)[CH2:24]1>>[CH3:13][O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[CH:5]=[C:4]([C:14]1[CH:19]=[CH:18][N:17]=[C:16]([NH:20][CH3:21])[N:15]=1)[CH:3]=[C:2]2[NH:1][CH:23]1[CH2:27][CH2:26][NH:25][CH2:24]1

Participants

3

Reactant 2

HCID 471360Tert-butyl 3-oxopyrrolidine-1-carboxylateHCID 583363954-(4-amino-6-methoxynaphthalen-2-yl)-N-methylpyrimidin-2-amine

Product 1

HCID 583364264-(6-methoxy-4-(pyrrolidin-3-ylamino)naphthalen-2-yl)-N-methylpyrimidin-2-amine

Procedure

4-(6-methoxy-4-(pyrrolidin-3-ylamino)naphthalen-2-yl)-N-methylpyrimidin-2-amine 148 was synthesized according to General Procedure E utilizing compound 33 and replacing tert-butyl 4-oxopiperidine-1-carboxylate with tert-butyl 3-oxopyrrolidine-1-carboxylate.

Sources & evidence

ORD record
ord-8c752cd114c14c3ea3dabd7edb7c8f51
Source dataset
uspto-grants-2012_05
Patent number
US08173808B2

Reaction notes

Loading…