Potassium Carbonate → HCID 12044217, compound

HRID 1922037Notes

Reaction equation

HRID 1922037 reaction equation
Br[CH2:2][CH:3]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH3:12])=[CH:7][N:6]=1)[OH:4].C(=O)([O-])[O-].[K+].[K+]>CO>[CH2:11]([C:8]1[CH:9]=[CH:10][C:5]([CH:3]2[CH2:2][O:4]2)=[N:6][CH:7]=1)[CH3:12]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 45095769HCID 45095769, compound

Product 1

HCID 12044217HCID 12044217, compoundYield 91.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a stirred solution of 10 g (0.0426 mol) of 2-bromo-1-(5-ethyl pyridin-2-yl)-ethanol dissolved in 50 mL of methanol, 6.86 g (0.0511 mol) potassium carbonate was added at 25-30° C. and stirring was continued for 1 hr. Subsequently filtered and methanol was concentrated to furnish 5.8 g (90%) of the desired product.

Workup

  1. filtrationSubsequently filtered
  2. concentrationmethanol was concentrated

Sources & evidence

ORD record
ord-72aac0ae41224d9daf09074413903b38
Source dataset
uspto-grants-2012_05
Patent number
US08173816B2

Reaction notes

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