反应详情

A mixture of [3-(4-aminobenzyl)-4-difluoromethoxy-2-ethyl-8-fluoroquinolin-5-yloxy]acetic acid methyl ester (0.051 g), pyridine (0.019 mL) and dichloromethane (0.5 mL) at 0° C. was treated with ethanesulfonyl chloride (0.013 mL) and the resulting mixture was stirred at room temperature overnight. The mixture was diluted with dichloromethane and water, and then acidified by the addition of glacial acetic acid. The organic phase was dried over magnesium sulfate, and then concentrated under reduced pressure to afford title compound as a yellow gum (0.051 g).

1. dry with materialThe organic phase was dried over magnesium sulfate
2. concentrationconcentrated under reduced pressure