3-Amino-4-fluorophenol → N-(2-fluoro-5-hydroxyphenyl)-3-oxo-2-(4-pyrazol-1-ylbenzyl)butyramide

HRID 1922098Notes

Reaction equation

HRID 1922098 reaction equation
C(S[C:6](=[O:23])[CH:7]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([N:18]2[CH:22]=[CH:21][CH:20]=[N:19]2)=[CH:14][CH:13]=1)[C:8](=[O:10])[CH3:9])(C)(C)C.[NH2:24][C:25]1[CH:26]=[C:27]([OH:32])[CH:28]=[CH:29][C:30]=1[F:31]>>[F:31][C:30]1[CH:29]=[CH:28][C:27]([OH:32])=[CH:26][C:25]=1[NH:24][C:6](=[O:23])[CH:7]([CH2:11][C:12]1[CH:13]=[CH:14][C:15]([N:18]2[CH:22]=[CH:21][CH:20]=[N:19]2)=[CH:16][CH:17]=1)[C:8](=[O:10])[CH3:9]

Participants

3

Reactant 2

HCID 135191803-Amino-4-fluorophenolHCID 866423723-oxo-2-(4-pyrazol-1-ylbenzyl)thiobutyric acid S-tert-butyl ester

Product 1

HCID 86642373N-(2-fluoro-5-hydroxyphenyl)-3-oxo-2-(4-pyrazol-1-ylbenzyl)butyramide

Procedure

The title compound was prepared by the method of Preparation 11b using 3-oxo-2-(4-pyrazol-1-ylbenzyl)thiobutyric acid S-tert-butyl ester and 3-amino-4-fluorophenol.

Sources & evidence

ORD record
ord-a599f213fd3343be8b3220424b64302b
Source dataset
uspto-grants-2012_05
Patent number
US08173812B2

Reaction notes

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