Chlorodifluoromethane → [8-Chloro-4-difluoromethoxy-2-ethyl-3-(4-isobutyrylbenzyl)quinolin-5-yloxy]acetic acid methyl ester

HRID 1922106Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1922106
[CH3:1][O:2][C:3](=[O:32])[CH2:4][O:5][C:6]1[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]2[C:7]=1[C:8](=[O:31])[C:9]([CH2:19][C:20]1[CH:25]=[CH:24][C:23]([C:26](=[O:30])[CH:27]([CH3:29])[CH3:28])=[CH:22][CH:21]=1)=[C:10]([CH2:17][CH3:18])[NH:11]2.Cl[CH:34]([F:36])[F:35]>>[CH3:1][O:2][C:3](=[O:32])[CH2:4][O:5][C:6]1[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]2[C:7]=1[C:8]([O:31][CH:34]([F:36])[F:35])=[C:9]([CH2:19][C:20]1[CH:21]=[CH:22][C:23]([C:26](=[O:30])[CH:27]([CH3:29])[CH3:28])=[CH:24][CH:25]=1)[C:10]([CH2:17][CH3:18])=[N:11]2

Komponenten

3

Edukt 2

HCID 6372ChlorodifluoromethaneHCID 67456772[8-Chloro-2-ethyl-3-(4-isobutyrylbenzyl)-4-oxo-1,4-dihydroquinolin-5-yloxy]acetic acid methyl ester

Produkt 1

HCID 67458281[8-Chloro-4-difluoromethoxy-2-ethyl-3-(4-isobutyrylbenzyl)quinolin-5-yloxy]acetic acid methyl ester

Versuchsvorschrift

The title compound was prepared by the method of Preparation 10c using [8-chloro-2-ethyl-3-(4-isobutyrylbenzyl)-4-oxo-1,4-dihydroquinolin-5-yloxy]acetic acid methyl ester and chlorodifluoromethane.

Quellen und Nachweise

ORD-Eintrag
ord-b0dd7f91068943d09bce5b26572a2cac
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08173812B2

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