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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1922106Generated: October 25, 2026

Chlorodifluoromethane → [8-Chloro-4-difluoromethoxy-2-ethyl-3-(4-isobutyrylbenzyl)quinolin-5-yloxy]acetic acid methyl ester

https://huagongshe.com/reaction/1922106

Reaction equation

Participants

RoleNameHCIDCharge
ReactantChlorodifluoromethaneHCID 6372—
Reactant[8-Chloro-2-ethyl-3-(4-isobutyrylbenzyl)-4-oxo-1,4-dihydroquinolin-5-yloxy]acetic acid methyl esterHCID 67456772—
Product[8-Chloro-4-difluoromethoxy-2-ethyl-3-(4-isobutyrylbenzyl)quinolin-5-yloxy]acetic acid methyl esterHCID 67458281—

Reaction Steps

The title compound was prepared by the method of Preparation 10c using [8-chloro-2-ethyl-3-(4-isobutyrylbenzyl)-4-oxo-1,4-dihydroquinolin-5-yloxy]acetic acid methyl ester and chlorodifluoromethane.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08173812B2
Source datasetuspto-grants-2012_05
ORD IDord-b0dd7f91068943d09bce5b26572a2cac
Source noteuspto-grants-2012_05