(3-Amino-4-fluorophenoxy)acetic acid methyl ester → [8-Fluoro-2-isopropyl-4-oxo-3-(4-pyrazol-1-ylbenzyl)-1,4-dihydroquinolin-5-yloxy]acetic acid methyl ester

HRID 1922121Notes

Reaction equation

HRID 1922121 reaction equation
[CH3:1][O:2][C:3](=[O:14])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([F:12])=[C:8]([NH2:13])[CH:7]=1.C([O:17][C:18](=O)[CH:19]([CH2:25][C:26]1[CH:31]=[CH:30][C:29]([N:32]2[CH:36]=[CH:35][CH:34]=[N:33]2)=[CH:28][CH:27]=1)[C:20](=O)[CH:21]([CH3:23])[CH3:22])C>>[CH3:1][O:2][C:3](=[O:14])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([F:12])=[C:8]2[C:7]=1[C:18](=[O:17])[C:19]([CH2:25][C:26]1[CH:31]=[CH:30][C:29]([N:32]3[CH:36]=[CH:35][CH:34]=[N:33]3)=[CH:28][CH:27]=1)=[C:20]([CH:21]([CH3:23])[CH3:22])[NH:13]2

Participants

3

Reactant 2

HCID 66717607(3-Amino-4-fluorophenoxy)acetic acid methyl esterHCID 674576524-Methyl-3-oxo-2-(4-pyrazol-1-ylbenzyl)pentanoic acid ethyl ester

Product 1

HCID 67459089[8-Fluoro-2-isopropyl-4-oxo-3-(4-pyrazol-1-ylbenzyl)-1,4-dihydroquinolin-5-yloxy]acetic acid methyl ester

Procedure

The title compound was prepared by the method of Preparation 1c using (3-amino-4-fluorophenoxy)acetic acid methyl ester and 4-methyl-3-oxo-2-(4-pyrazol-1-ylbenzyl)pentanoic acid ethyl ester.

Sources & evidence

ORD record
ord-8b2c83a4860c41cab89aac85816190b4
Source dataset
uspto-grants-2012_05
Patent number
US08173812B2

Reaction notes

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