反应详情

A mixture of {4-difluoromethoxy-2-ethyl-8-fluoro-3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)benzyl]quinolin-5-yloxy}acetic acid methyl ester (0.89 g), sodium periodate (1.7 g), ammonium acetate (0.46 g), acetone (23 mL) and water (11 mL) was stirred at room temperature for 41 hours. The mixture was concentrated to low bulk under reduced pressure, and the residue was diluted with water and then extracted with ethyl acetate. The combined extracts were washed with saturated aqueous sodium chloride solution, dried over magnesium sulphate and then concentrated under reduced pressure to afford title compound (0.70 g).

1. concentrationThe mixture was concentrated to low bulk under reduced pressure
2. additionthe residue was diluted with water
3. extractionextracted with ethyl acetate
4. washThe combined extracts were washed with saturated aqueous sodium chloride solution
5. dry with materialdried over magnesium sulphate
6. concentrationconcentrated under reduced pressure