Chlorodifluoromethane → HCID 67459090, compound

HRID 1922144Notes

Reaction equation

[C:1]([O:5][C:6](=[O:30])[CH2:7][O:8][C:9]1[CH:18]=[CH:17][C:16]([F:19])=[C:15]2[C:10]=1[C:11]([CH3:29])=[C:12]([CH2:21][C:22]1[CH:27]=[CH:26][C:25]([Br:28])=[CH:24][CH:23]=1)[C:13](=[O:20])[NH:14]2)([CH3:4])([CH3:3])[CH3:2].Cl[CH:32]([F:34])[F:33]>>[C:1]([O:5][C:6](=[O:30])[CH2:7][O:8][C:9]1[CH:18]=[CH:17][C:16]([F:19])=[C:15]2[C:10]=1[C:11]([CH3:29])=[C:12]([CH2:21][C:22]1[CH:23]=[CH:24][C:25]([Br:28])=[CH:26][CH:27]=1)[C:13]([O:20][CH:32]([F:34])[F:33])=[N:14]2)([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 6372Chlorodifluoromethane

HCID 67456317HCID 67456317, compound

Product 1

HCID 67459090HCID 67459090, compound

Procedure

The title compound was prepared by the method of Preparation 10c using [3-(4-bromobenzyl)-8-fluoro-4-methyl-2-oxo-1,2-dihydroquinolin-5-yloxy]acetic acid tert-butyl ester and chlorodifluoromethane.

Sources & evidence

ORD record: ord-a1860b4ae97248689ae7e385d1aeed2b
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08173812B2

Reaction notes

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