HRID1922145

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13163973

4-Cyclopropyl-1H-pyrazole

C6H8N2

结构：Cc1c(Cc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)c(OC(F)F)nc2c(Cl)ccc(OCC(=O)OC(C)(C)C)c12

HCID67458465

未命名化合物

PRODUCTS

生成物

结构：Cc1c(Cc2ccc(-n3cc(C4CC4)cn3)cc2)c(OC(F)F)nc2c(Cl)ccc(OCC(=O)OC(C)(C)C)c12

HCID67457844

未命名化合物

PROCEDURE

实验过程

The title compounds was prepared by the method of Preparation 18a using {8-chloro-2-difluoromethoxy-4-methyl-3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)benzyl]quinolin-5-yloxy}acetic acid tert-butyl ester and 4-cyclopropyl-1H-pyrazole.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b3d1631b178640b5be04d247bbfc9e86
来源数据集: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08173812B2
来源说明: uspto-grants-2012_05

反应 SMILES

[C:1]([O:5][C:6](=[O:41])[CH2:7][O:8][C:9]1[CH:18]=[CH:17][C:16]([Cl:19])=[C:15]2[C:10]=1[C:11]([CH3:40])=[C:12]([CH2:24][C:25]1[CH:30]=[CH:29][C:28](B3OC(C)(C)C(C)(C)O3)=[CH:27][CH:26]=1)[C:13]([O:20][CH:21]([F:23])[F:22])=[N:14]2)([CH3:4])([CH3:3])[CH3:2].[CH:42]1([C:45]2[CH:46]=[N:47][NH:48][CH:49]=2)[CH2:44][CH2:43]1>>[C:1]([O:5][C:6](=[O:41])[CH2:7][O:8][C:9]1[CH:18]=[CH:17][C:16]([Cl:19])=[C:15]2[C:10]=1[C:11]([CH3:40])=[C:12]([CH2:24][C:25]1[CH:30]=[CH:29][C:28]([N:47]3[CH:46]=[C:45]([CH:42]4[CH2:44][CH2:43]4)[CH:49]=[N:48]3)=[CH:27][CH:26]=1)[C:13]([O:20][CH:21]([F:22])[F:23])=[N:14]2)([CH3:4])([CH3:2])[CH3:3]