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4-Cyclopropyl-1H-pyrazole → {8-Chloro-3-[4-(4-cyclopropylpyrazol-1-yl)benzyl]-2-difluoromethoxy-4-methylquinolin-5-yloxy}acetic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Cyclopropyl-1H-pyrazole | HCID 13163973 | — |
| 反応物 | {8-Chloro-2-difluoromethoxy-4-methyl-3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)benzyl]quinolin-5-yloxy}acetic acid tert-butyl ester | HCID 67458465 | — |
| 生成物 | {8-Chloro-3-[4-(4-cyclopropylpyrazol-1-yl)benzyl]-2-difluoromethoxy-4-methylquinolin-5-yloxy}acetic acid tert-butyl ester | HCID 67457844 | — |
反応手順
The title compounds was prepared by the method of Preparation 18a using {8-chloro-2-difluoromethoxy-4-methyl-3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)benzyl]quinolin-5-yloxy}acetic acid tert-butyl ester and 4-cyclopropyl-1H-pyrazole.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08173812B2 |
| 出典データセット | uspto-grants-2012_05 |
| ORD ID | ord-b3d1631b178640b5be04d247bbfc9e86 |
| 出典メモ | uspto-grants-2012_05 |