HRID1922147

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID27524

1H-Pyrazole, 4-chloro- (9CI)

C3H3ClN2

结构：Cc1c(Cc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)c(OC(F)F)nc2c(Cl)ccc(OCC(=O)OC(C)(C)C)c12

HCID67458465

未命名化合物

PRODUCTS

生成物

结构：Cc1c(Cc2ccc(-n3cc(Cl)cn3)cc2)c(OC(F)F)nc2c(Cl)ccc(OCC(=O)OC(C)(C)C)c12

HCID67456421

未命名化合物

PROCEDURE

实验过程

The title compound was prepared by the method of Preparation 18a using {8-chloro-2-difluoromethoxy-4-methyl-3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)benzyl]quinolin-5-yloxy}acetic acid tert-butyl ester and 4-chloro-1H-pyrazole.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1f2e9b8a933b495cb8a278918741f0eb
来源数据集: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08173812B2
来源说明: uspto-grants-2012_05

反应 SMILES

[C:1]([O:5][C:6](=[O:41])[CH2:7][O:8][C:9]1[CH:18]=[CH:17][C:16]([Cl:19])=[C:15]2[C:10]=1[C:11]([CH3:40])=[C:12]([CH2:24][C:25]1[CH:30]=[CH:29][C:28](B3OC(C)(C)C(C)(C)O3)=[CH:27][CH:26]=1)[C:13]([O:20][CH:21]([F:23])[F:22])=[N:14]2)([CH3:4])([CH3:3])[CH3:2].[Cl:42][C:43]1[CH:44]=[N:45][NH:46][CH:47]=1>>[C:1]([O:5][C:6](=[O:41])[CH2:7][O:8][C:9]1[CH:18]=[CH:17][C:16]([Cl:19])=[C:15]2[C:10]=1[C:11]([CH3:40])=[C:12]([CH2:24][C:25]1[CH:26]=[CH:27][C:28]([N:45]3[CH:44]=[C:43]([Cl:42])[CH:47]=[N:46]3)=[CH:29][CH:30]=1)[C:13]([O:20][CH:21]([F:23])[F:22])=[N:14]2)([CH3:2])([CH3:3])[CH3:4]