HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-Pyrazole, 4-chloro- → {8-Chloro-3-[4-(4-chloropyrazol-1-yl)benzyl]-2-difluoromethoxy-4-methylquinolin-5-yloxy}acetic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-Pyrazole, 4-chloro- | HCID 27524 | — |
| Reactant | {8-Chloro-2-difluoromethoxy-4-methyl-3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)benzyl]quinolin-5-yloxy}acetic acid tert-butyl ester | HCID 67458465 | — |
| Product | {8-Chloro-3-[4-(4-chloropyrazol-1-yl)benzyl]-2-difluoromethoxy-4-methylquinolin-5-yloxy}acetic acid tert-butyl ester | HCID 67456421 | — |
Reaction Steps
The title compound was prepared by the method of Preparation 18a using {8-chloro-2-difluoromethoxy-4-methyl-3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)benzyl]quinolin-5-yloxy}acetic acid tert-butyl ester and 4-chloro-1H-pyrazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173812B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-1f2e9b8a933b495cb8a278918741f0eb |
| Source note | uspto-grants-2012_05 |