HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 86646589, compound → 3-(2-Cyclobutylacetyl)pyrrolidine-1-carboxylic acid tert butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 86646589 | HCID 86646589 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-(2-Cyclobutylacetyl)pyrrolidine-1-carboxylic acid tert butyl ester | HCID 86646590 | 46% |
Reaction Steps
Add palladium on carbon (50 mg, catalytic) to 3-(2-cyclobutylidene-acetyl)pyrrolidine-1-carboxylic acid tert butyl ester (850 mg, 3.20 mmol) in ethyl acetate (25 mL) and stir under nitrogen at room temperature. Install a balloon of hydrogen gas and stir overnight. Filter the reaction over celite, rinse with ethyl acetate and concentrate to dryness to afford 391 mg (46%) of the desired compound. MS (m/z)=212.0 (M−55)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173821B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-92b29a1f4cbe496f8f5460dcbd3656ad |
| Source note | uspto-grants-2012_05 |