反应详情

Add palladium on carbon (50 mg, catalytic) to 3-(2-cyclobutylidene-acetyl)pyrrolidine-1-carboxylic acid tert butyl ester (850 mg, 3.20 mmol) in ethyl acetate (25 mL) and stir under nitrogen at room temperature. Install a balloon of hydrogen gas and stir overnight. Filter the reaction over celite, rinse with ethyl acetate and concentrate to dryness to afford 391 mg (46%) of the desired compound. MS (m/z)=212.0 (M−55)

1. filtrationFilter
2. customthe reaction over celite
3. washrinse with ethyl acetate
4. concentrationconcentrate to dryness