Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(1S,2R)-(-)-1-Amino-2-indanol → 4-[2-((1S,2R)-2-Hydroxy-indan-1-ylamino)-benzooxazol-6-yloxy]-pyridine-2-carboxylic acid methylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (1S,2R)-(-)-1-Amino-2-indanol | HCID 9866743 | — |
| 반응물 | N-methyl-4-(2-(methylsulfinyl)benzo[d]oxazol-6-yloxy)picolinamide | HCID 57725414 | — |
| 용매 | Dimethylacetamide | HCID 31374 | — |
| 생성물 | 4-[2-((1S,2R)-2-Hydroxy-indan-1-ylamino)-benzooxazol-6-yloxy]-pyridine-2-carboxylic acid methylamide | HCID 24821930 | — |
반응 단계
A solution of 4-(2-(methylsulfinyl)benzo[d]oxazol-6-yloxy)-N-methylpyridine-2-carboxamide (17 mg, 0.05 mmol, 1.0 eq) and (1S,2R)-1-amino-2,3-dihydro-1H-inden-2-ol (30 mg, 0.2 mml, 4.0 eq) in 1 mL of N,N-dimethylacetamide was heated in the microwave at 90° C. for 600 seconds. The crude product was purified by reverse phase prep HPLC to give the title compound. MH==417.0.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08173689B2 |
| 출처 데이터셋 | uspto-grants-2012_05 |
| ORD ID | ord-8395b77cedfe4b69811e4438150581e4 |
| 출처 메모 | uspto-grants-2012_05 |