HCID 20033286, compound → HCID 20033363, compound

HRID 1922207Notes

Reaction equation

HRID 1922207 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)[CH:7]=[CH:8][CH:9]=1)([O-])=O.[H][H]>C(O)C.[Pd]>[N:12]1([CH2:11][CH2:10][C:6]2[CH:5]=[C:4]([NH2:1])[CH:9]=[CH:8][CH:7]=2)[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

Participants

5

Reactant 2

HCID 20033286HCID 20033286, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20033363HCID 20033363, compoundYield 60%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of 1-[2-(3-Nitro-phenyl)-ethyl]-piperidine in ethanol was added a catalytic amount 10% activated palladium on carbon and excess hydrogen gas. This mixture was allowed to stir overnight, then filtered and concentrated. The product was clean enough for the next reaction. 60% yield. MH+=205.1.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated
  3. customThe product was clean enough for the next reaction

Sources & evidence

ORD record
ord-c0b77b4c589e4856ba8d2c1008ba4aed
Source dataset
uspto-grants-2012_05
Patent number
US08173689B2

Reaction notes

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