反应详情

To the solution of 4-(7-chloro-2-(methylthio)benzo[d]thiazol-6-yloxy)-N-methylpicolinamide (64 mg, 0.175 mmol, 1.0 eq) in 5 mL of DCM was added MCPBA (33 mg, 0.192 mmol, 1.1 eq) at 0° C. and reaction stirred for 30-45 min. Thereafter, it was quenched with water (10 mL) and aqueous phase extracted with ethyl acetate (25 mL×5), combined organic layers dried over sodium sulfate, filtered and condensed under reduced pressure to yield crude product which was sufficiently pure and was carried to next step without further purification. LC/MS (m/z) [382.0] (MH+)

1. customreaction
2. customThereafter, it was quenched with water (10 mL) and aqueous phase
3. extractionextracted with ethyl acetate (25 mL×5)
4. dry with materialdried over sodium sulfate
5. filtrationfiltered
6. customcondensed under reduced pressure
7. customto yield crude product which
8. customwas carried to next step without further purification