Dichloromethane → (S)-N-(5-bromo-2,3-dihydro-1H-inden-2-yl)propane-2-sulfonamide

HRID 1922291Notes

Reaction equation

HRID 1922291 reaction equation
[C:1]12([CH2:11][S:12]([OH:15])(=[O:14])=O)C(C)(C)C(CC1)CC2=O.[Br:16][C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][CH:25]=1)[CH2:22][C@H:21]([NH2:26])[CH2:20]2.[CH2:27](Cl)Cl>>[Br:16][C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][CH:25]=1)[CH2:22][C@H:21]([NH:26][S:12]([CH:11]([CH3:1])[CH3:27])(=[O:14])=[O:15])[CH2:20]2

Participants

3

Reactant 2

HCID 6344DichloromethaneHCID 86650331(s)-5-Bromo-2-aminoindane camphorsulfonate salt

Product 1

HCID 46899974(S)-N-(5-bromo-2,3-dihydro-1H-inden-2-yl)propane-2-sulfonamide

Procedure

N-[(2S)-5-bromo-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide was prepared using a similar method to that disclosed in WO 2006/015828; the initial solvent for conversion of (S)-5-bromo-2-aminoindane camphorsulfonate salt into the free base form was DCM.

Sources & evidence

ORD record
ord-b6da3761a99a4a3aa31ae4344bb8d355
Source dataset
uspto-grants-2012_05
Patent number
US08173820B2

Reaction notes

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