反应详情

A solution of compound 4 (0.8 g, 3.208 mmol) in dry ethanol (20 mL) was treated with Pd—C (˜0.08 g) and purged with hydrogen gas. The reaction was stirred at room temperature under hydrogen atm. for 3 h. The reaction was filtered through celite bed and washed with methanol (3×20 mL). The combined organic layer was evaporated and crude was purified by column chromatography (2 M NH3 in MeOH:CH2Cl2, 5:95) to obtain compound 5 (0.6 g, 86%).

1. custompurged with hydrogen gas
2. filtrationThe reaction was filtered through celite bed
3. washwashed with methanol (3×20 mL)
4. customThe combined organic layer was evaporated
5. customcrude was purified by column chromatography (2 M NH3 in MeOH:CH2Cl2, 5:95)