N,N-Dimethyl-2-(7-nitro-3,4-dihydroquinolin-1(2H)-yl)ethanamine → 7-Amino-1-(2-dimethylaminoethyl)-1,2,3,4-tetrahydroquinoline

関与物質

反応手順

A solution of compound 4 (0.8 g, 3.208 mmol) in dry ethanol (20 mL) was treated with Pd—C (˜0.08 g) and purged with hydrogen gas. The reaction was stirred at room temperature under hydrogen atm. for 3 h. The reaction was filtered through celite bed and washed with methanol (3×20 mL). The combined organic layer was evaporated and crude was purified by column chromatography (2 M NH3 in MeOH:CH2Cl2, 5:95) to obtain compound 5 (0.6 g, 86%).

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