反应详情

To a stirred solution of phenyl methyl(3-(6-nitro-3,4-dihydroquinolin-1(2H)-yl)propyl)carbamate (1.02 g, 2.76 mmol) in THF (15.00 ml) and ethanol (15 ml) was added palladium 10 wt. % on activated carbon (0.294 g, 0.276 mmol). The reaction mixture was stirred under an atmosphere of hydrogen (balloon pressure) for 3 h. The mixture was then filtered through celite and concentrated, giving a dark oil. The crude product (phenyl 3-(6-amino-3,4-dihydroquinolin-1(2H)-yl)propyl(methyl)carbamate (830 mg, 2.445 mmol, 89% yield)) was used directly in the subsequent reaction. ESI-MS (m/z, %) 340 (MH+, 100).

1. filtrationThe mixture was then filtered through celite
2. concentrationconcentrated
3. customgiving a dark oil