反应详情

To a stirred solution of 4-(3-(6-nitro-3,4-dihydroquinolin-1(2H)-yl)propyl)morpholine (250 mg, 0.819 mmol) in Ethanol (4 ml) and Tetrahydrofuran (4.00 ml) was added Palladium on activated carbon, 10 wt. % (87 mg, 0.082 mmol). The reaction was then stirred under a hydrogen atmosphere (balloon pressure) for 2 h. When TLC analysis showed that the starting material was consumed, the mixture was filtered through a pad of celite which was then washed with methanol. The filtrate was concentrated, giving the desired 1-(3-morpholinopropyl)-1,2,3,4-tetrahydroquinolin-6-amine (190 mg, 0.690 mmol, 84% yield) as a dark oil.

1. customwas consumed
2. filtrationthe mixture was filtered through a pad of celite which
3. washwas then washed with methanol
4. concentrationThe filtrate was concentrated