Hydroxide → 2-(4-Carboxy-2-methoxy-phenylamino)-4-chloro-5-trifluoromethyl-pyrimidine

HRID 192256Notes

Reaction equation

HRID 192256 reaction equation
[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[Cl:1][c:2]1[n:3][c:4]([NH:12][c:13]2[c:14]([O:29][CH3:30])[cH:15][c:16]([C:17](=[O:18])[O:19][CH2:20][c:21]3[cH:22][cH:23][cH:24][cH:25][cH:26]3)[cH:27][cH:28]2)[n:5][cH:6][c:7]1[C:8]([F:9])([F:10])[F:11].[OH-:36].[OH-:37].[Pd+2:38]>>[Cl:1][c:2]1[n:3][c:4]([NH:12][c:13]2[c:14]([O:29][CH3:30])[cH:15][c:16]([C:17](=[O:18])[OH:19])[cH:27][cH:28]2)[n:5][cH:6][c:7]1[C:8]([F:9])([F:10])[F:11]

Participants

5

Reactant 4

HCID 961Hydroxide2×HCID 8028TetrahydrofuranHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 582010032-(4-Benzyloxycarbonyl-2-methoxy-phenylamino)-4-chloro-5-trifluoromethyl-pyrimidine

Product 1

HCID 589063992-(4-Carboxy-2-methoxy-phenylamino)-4-chloro-5-trifluoromethyl-pyrimidine

Sources & evidence

ORD record
ord-7ea398ed5cbc44e1a11b0d2ed480ccdc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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