Ammonium Hydroxide → HCID 59605867, compound

HRID 1923274Notes

Reaction equation

[CH3:1][CH:2]([CH3:38])[CH:3]([N:7]1[CH2:10][CH:9]([CH2:11][C:12]2[N:13]([CH3:37])[C:14]3[C:19]([N:20]=2)=[C:18]([N:21]2[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)[N:17]=[C:16]([N:27]2[C:31]4[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=4[N:29]=[C:28]2[CH3:36])[N:15]=3)[CH2:8]1)[C:4]([OH:6])=O.[OH-].[NH4+:40]>>[CH3:1][CH:2]([CH3:38])[CH:3]([N:7]1[CH2:10][CH:9]([CH2:11][C:12]2[N:13]([CH3:37])[C:14]3[C:19]([N:20]=2)=[C:18]([N:21]2[CH2:22][CH2:23][O:24][CH2:25][CH2:26]2)[N:17]=[C:16]([N:27]2[C:31]4[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=4[N:29]=[C:28]2[CH3:36])[N:15]=3)[CH2:8]1)[C:4]([NH2:40])=[O:6]

Participants

Reactant 2

HCID 14923Ammonium Hydroxide

HCID 59605380HCID 59605380, compound

Product 1

HCID 59605867HCID 59605867, compound

Procedure

Following General Procedure K, 3-methyl-2-(3-((9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-6-morpholino-9H-purin-8-yl)methyl)azetidin-1-yl)butanoic acid and ammonium hydroxide were coupled to give 579. LCMS m/z: 259.7 (2M+H+)

Sources & evidence

ORD record: ord-41de9aff20694a1b9fa6c62be4b3db55
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08173650B2

Reaction notes

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