Hydrochloric Acid → HCID 67401067, compound

HRID 1923404Notes

Reaction equation

HRID 1923404 reaction equation
[N:1]12[CH2:8][CH2:7][C:4]([CH:9]=[CH:10][C:11]([O:13]CC)=[O:12])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[ClH:16]>>[ClH:16].[N:1]12[CH2:8][CH2:7][C:4]([CH:9]=[CH:10][C:11]([OH:13])=[O:12])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 54409371HCID 54409371, compound

Product 1

HCID 67401067HCID 67401067, compoundYield 60%

Procedure

Ethyl 3-(quinuclidin-4-yl)-acrylate (0.7 g, 0.0033 moles) was heated under reflux in 5 molar hydrochloric acid (30 ml) for 18 hours, cooled then concentrated in vacuo to an oil. Trituration with acetone gave the title compound as an off-white solid 0.43 g (60%). MS (+ve ion electrospray) m/z 182 (MH+, 100%).

Workup

  1. temperaturecooled
  2. concentrationthen concentrated in vacuo to an oil

Sources & evidence

ORD record
ord-493d20a00cd142f5863935afc15908a4
Source dataset
uspto-grants-2012_05
Patent number
USRE043390E1

Reaction notes

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