Methylamine → HCID 67521226, compound

HRID 1923429Notes

Reaction equation

HRID 1923429 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH2:9][C:10]2[CH:23]=[CH:22][C:13]([CH2:14][NH:15]C(=O)C(F)(F)F)=[CH:12][CH:11]=2)[CH:5]=[CH:4][N:3]=1.CN>CO>[NH2:15][CH2:14][C:13]1[CH:12]=[CH:11][C:10]([CH2:9][O:8][C:6]2[CH:5]=[CH:4][N:3]=[C:2]([NH2:1])[N:7]=2)=[CH:23][CH:22]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 86632758HCID 86632758, compound

Product 1

HCID 67521226HCID 67521226, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

50 mg (1.53 mmol) N-[4-(2-Amino-pyrimidin-4-yloxymethyl)-benzyl]-2,2,2-trifluoro-acetamide (5) is dissolved in 1 mL methanol and treated with 2 mL methylamine (33% in ethanol). The reaction mixture is stirred at room temperature over night and all volatiles are removed in vacuo. The product is used without further purification in the next step. ESI-MS m/z 231.4 [M+H]+.

Workup

  1. customall volatiles are removed in vacuo
  2. customThe product is used without further purification in the next step

Sources & evidence

ORD record
ord-5d2509e477fa41908009872ca4b89650
Source dataset
uspto-grants-2012_05
Patent number
US08178314B2

Reaction notes

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