Methylamine → HCID 86632761, compound

HRID 1923433Notes

Reaction equation

HRID 1923433 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([O:9][CH2:10][C:11]2[CH:24]=[CH:23][C:14]([CH2:15][NH:16]C(=O)C(F)(F)F)=[CH:13][CH:12]=2)[N:3]=1.CN>CO>[NH2:16][CH2:15][C:14]1[CH:23]=[CH:24][C:11]([CH2:10][O:9][C:4]2[N:3]=[C:2]([NH2:1])[N:7]=[C:6]([Cl:8])[CH:5]=2)=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 86632760HCID 86632760, compound

Product 1

HCID 86632761HCID 86632761, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

65 mg (0.18 mmol) N-[4-(2-amino-4-chloropyrimidin-6-yloxymethyl)-benzyl]-2,2,2-trifluoro-acetamide (15) is dissolved in 1 mL methanol and treated with 2 mL methylamine (33% in ethanol). The reaction mixture is stirred at room temperature over night and all volatiles are removed in vacuo. The product is used without further purification in the next step. ESI-MS m/z 265.3 [M+H]+.

Workup

  1. customall volatiles are removed in vacuo
  2. customThe product is used without further purification in the next step

Sources & evidence

ORD record
ord-d0960e1996ce43ad951cb9cc18c382a1
Source dataset
uspto-grants-2012_05
Patent number
US08178314B2

Reaction notes

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