Propane sultone → 3-(5-Hydroxy-3,4-dihydro-2h-quinoline-1-yl)propanesulfonic acid

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.8 g (5.36 mmol) of 5-hydroxy-1,2,3,4-tetrahydroquinoline and 0.5 g 1,3-propanesultone (4.1 mmol) in 12 ml of butyronitrile was heated at 125° C. for hours. The mixture was suction filtered and the filtrate evaporated under reduced pressure. The resulting off white compound crystallized. Product washed with ethyl ether and filtered of. Yield 0.8 g (80%)

Provenance & Evidence