4-Bromobenzoic acid → HCID 57980136, compound

HRID 1923477Notes

Reaction equation

HRID 1923477 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][CH:3]=1.[CH3:11][C@@H:12]1[CH2:16][CH2:15][CH2:14][N:13]1[CH2:17][C@@H:18]1[CH2:22][CH2:21][CH2:20][NH:19]1.S(Cl)(Cl)=O>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([N:19]2[CH2:20][CH2:21][CH2:22][C@H:18]2[CH2:17][N:13]2[CH2:14][CH2:15][CH2:16][C@H:12]2[CH3:11])=[O:8])=[CH:9][CH:10]=1

Participants

4

Reactant 3

HCID 114644-Bromobenzoic acidHCID 24386Thionyl ChlorideHCID 46911921(R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidine

Product 1

HCID 57980136HCID 57980136, compound

Procedure

The title compound is prepared in a manner substantially analogous to Procedure C using commercially available 4-bromo benzoic acid, 2-(R)-methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine, and thionyl chloride in place of oxalyl chloride. (MS (ES+) 352.3 (M+H)+

Sources & evidence

ORD record
ord-d45368454a7f42c5aaa130062b03e20c
Source dataset
uspto-grants-2012_05
Patent number
US08178528B2

Reaction notes

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